Research on the longevity genetics in Indians has illuminated unique pathways and variants associated with long-lived individuals (LLIs), defined as those aged 85 and above. GenomegaDB is a comprehensive genetic database specifically developed to map the genetic diversity of the Indian population. It addresses the underrepresentation of Indian genomes in global genetic studies and provides a critical resource for understanding population-specific health traits, including ageing and longevity. By comparing the genomes of LLIs with younger controls, the study uncovered genetic markers that influence healthspan and ageing trajectories tailored to the Indian context.
Key findingsUnique Genetic Variants:
Variants associated with decreased risk of osteoporosis (ESR1), slower heart rate (MYH6) and reduced anxiety (HSPA5) were more frequent in LLIs. These traits are linked to better cardiac, skeletal and mental health, contributing to extended lifespan.
Conversely, variants tied to atrial fibrillation (GORAB-PRRX1) and schizophrenia (RIMS1- KCNQ5) were less frequent in LLIs, suggesting that avoiding these risk factors plays a protective role in longevity.
Variants linked to shorter stature were also more common in LLIs, aligning with findings that reduced growth hormone and IGF-1 activity, lower caloric needs and potentially better cardiovascular health – often associated with shorter stature – may be linked to longer lifespan.
FOXO3A and APOE Genes:
The FOXO3A...
Read more
-
Not Sooryavanshi Or Mhatre: Former India Star Picks This Batsman As Best Young Talent
-
West Bengal Assembly Elections 2026: Key Faces, Key Seats And High-Stakes Battles
-
Centre Flags Surge in Online Bookings Amid Gas Cylinder Shortage
-
Trump Accuses Iran Of Repeated Ceasefire Violations; Islamabad Talks Uncertain
-
Action-Packed Finals Conclude 45th Willingdon Catholic Gymkhana Rink Hockey Tournament In Style
